CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]

Stable Identifier
R-HSA-109291
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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5'-nucleotidase (NT5E) associated with the plasma membrane catalyzes the reactions of extracellular CMP, TMP, or UMP with H2O to yield the corresponding nucleoside and orthophosphate. The active enzyme is a glycolipid-anchored dimer (Misumi et al. 1990; Thompson et al. 1987; Zimmerman 1992)

Literature References
PubMed ID Title Journal Year
2129526 Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form

Misumi, Y, Ogata, S, Ohkubo, K, Hirose, S, Ikehara, Y

Eur J Biochem 1990
2826576 Distribution of ecto-5'-nucleotidase on subsets of human T and B lymphocytes as detected by indirect immunofluorescence using goat antibodies

Thompson, LF, Ruedi, JM, Low, MG, Clement, LT

J. Immunol. 1987
16377327 The importance of having a mentor, and how to find one

Stone, CD

Gastrointest. Endosc. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
5'-nucleotidase activity of NT5E:Zn2+ dimer [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Created