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Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation
Stable Identifier
R-HSA-109339
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Mitochondrial Fatty Acid Beta-Oxidation (Homo sapiens)
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (Homo sapiens)
Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Three cycles of beta oxidation, each mediated by the activities of trifunctional protein and ACADL tetramer, convert linoleoyl-CoA to cis,cis-3,6-dodecadienoyl-CoA plus three molecules each of CoA-SH, FADH2, and NADH + H+.
Literature References
PubMed ID
Title
Journal
Year
The Metabolic and Molecular Bases of Inherited Disease, 8th ed
Beaudet, AL
,
Scriver, CR
,
Sly, WS
,
Valle, D
2001
Participants
Input
x 3
CoA-SH [mitochondrial matrix]
x 3
FAD [mitochondrial matrix]
x 3
H2O [mitochondrial matrix]
LIN-CoA [mitochondrial matrix]
x 3
NAD+ [mitochondrial matrix]
Output
x 3
Ac-CoA [mitochondrial matrix]
cis,cis-3,6-Dodecadienoyl-CoA [mitochondrial matrix]
x 3
FADH2 [mitochondrial matrix]
x 3
H+ [mitochondrial matrix]
x 3
NADH [mitochondrial matrix]
Participates
as an event of
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (Homo sapiens)
Event Information
Go Biological Process
fatty acid beta-oxidation (0006635)
This event is regulated
Requirements
Requirement by 'Trifunctional Protein [mitochondrial matrix]'
Requirement by 'ACADL tetramer [mitochondrial matrix]'
Authored
Gillespie, ME (2004-01-19)
Created
Gillespie, ME (2004-01-02)
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