(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A)

Stable Identifier
R-HSA-109387
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
(2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A]
Locations in the PathwayBrowser
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Cytosolic 5'-nucleotidase IA catalyzes the hydrolysis of purine ribo- and deoxyribonucleoside monophosphates to nucleosides plus orthophosphate. The enzyme is allosterically activated by ADP (Hunsucker et al. 2001). The human enzyme is inferred to be a homotetramer with one Mg++ ion bound per subunit, based on its similarity to the pigeon heart enzyme (Bianchi and Spychala 2003; Sala-Newby et al. 1999; Skladanowski and Newby 1990).

Literature References
PubMed ID Title Journal Year
10364222 The mechanism of adenosine formation in cells. Cloning of cytosolic 5'-nucleotidase-I

Sala-Newby, GB, Skladanowski, A, Newby, AC

J Biol Chem 1999
11133996 Human cytosolic 5'-nucleotidase I. Characterization and role in nucleoside analog resistance

Hunsucker, SA, Spychala, J, Mitchell, BS

J Biol Chem 2001
12947102 Mammalian 5'-nucleotidases

Bianchi, V, Spychala, J

J Biol Chem 2003
2344353 Partial purification and properties of an AMP-specific soluble 5'-nucleotidase from pigeon heart

Skladanowski, A, Newby, AC

Biochem J 1990
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
5'-nucleotidase activity of NT5C1A tetramer [cytosol]
Physical Entity
Activity
This event is regulated
Positively by
Orthologous Events
Cross References
Rhea
Created