Reactome | (d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)

(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)

Stable Identifier

R-HSA-109470

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)

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Cytosolic 5'3'-nucleotidase (NT5C) catalyzes the hydrolysis of deoxy- and ribo- guanosine and inosine nucleoside monophosphates to yield the corresponding nucleosides and orthophosphate. The active form of the enzyme is a homodimer, with an absolute requirement for Mg++ (Hoglund and Reichard 1990; Rampazzo et al. 2000). This enzyme appears to play a central role in the "substrate cycles" that regulate cytosolic deoxynucleotide levels (Gazziola et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
2157703	Cytoplasmic 5'(3')-nucleotidase from human placenta Hoglund, L, Reichard, PA	J Biol Chem	1990
11083867	Cytosolic high Km 5'-nucleotidase and 5'(3')-deoxyribonucleotidase in substrate cycles involved in nucleotide metabolism Bianchi, V, Moras, M, Reichard, PA, Ferraro, P, Gazziola, C	J Biol Chem	2001
10681516	Mammalian 5'(3')-deoxyribonucleotidase, cDNA cloning, and overexpression of the enzyme in Escherichia coli and mammalian cells Bianchi, V, Reichard, PA, Karlsson, A, Ferraro, P, Gallinaro, L, Hellman, U, Rampazzo, C, Johansson, M	J Biol Chem	2000