(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)

Stable Identifier
R-HSA-109624
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic adenosine linase (ADK) catalyzes the reactions of adenosine and deoxyadenosine with ATP to yield the corresponding nucleotide monophosphates and ADP (Andres and Fox 1979). The enzyme is substantially more active on adenosine than deoxyadenosine in vitro (Hurley at al. 1985) though studies of cultured cells suggest that both reactions may be physiologically relevant (Hershfield et al. 1982). The enzyme is a monomer complexed with magnesium (Mathews et al. 1998).

Literature References
PubMed ID Title Journal Year
6281270 Effects of mutational loss of adenosine kinase and deoxycytidine kinase on deoxyATP accumulation and deoxyadenosine toxicity in cultured CEM human T-lymphoblastoid cells

Hershfield, MS, Fetter, JE, Small, WC, Bagnara, AS, Williams, SR, Ullman, B, Martin, Jr, DW, Wasson, DB, Carson, DA

J Biol Chem 1982
9843365 Structure of human adenosine kinase at 1.5 A resolution.

Mathews, II, Erion, MD, Ealick, SE

Biochemistry 1998
2999129 Regulation of deoxyadenosine and nucleoside analog phosphorylation by human placental adenosine kinase

Hurley, MC, Lin, B, Fox, IH

J Biol Chem 1985
227870 Purification and properties of human placental adenosine kinase

Andres, CM, Fox, IH

J Biol Chem 1979
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
adenosine kinase activity of ADK [cytosol]
Physical Entity
Activity
Orthologous Events
Created