Recognition and Binding of Core Promoter Elements by TFIID

Stable Identifier
R-HSA-109636
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Although TBP (TATA box binding factor) is necessary and sufficient for initiation of basal transcription, the other subunits of the general transcription factor TFIID, the TBP-associated factors, are required for response to transcriptional activators. TBP binds to the TATA box (a core promoter element), and bends the DNA 80 degrees toward the major groove. This conformation of TBP-TATA box provides the proper topology for the binding of the general transcription factor TFIIB.

Transcriptional activators function by affecting the kinetics of binding of TBP to the promoter DNA.

Literature References
PubMed ID Title Journal Year
8946909 The general transcription factors of RNA polymerase II.

Orphanides, G, Lagrange, T, Reinberg, D

Genes Dev 1997
8330735 TBP, a universal eukaryotic transcription factor?

Hernandez, N

Genes Dev 1993
Participants
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Authored
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