Formation of the closed pre-initiation complex

Stable Identifier
R-HSA-109639
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The binding of TFIIH completes the assembly of the preinitiation complex (PIC) for RNA Polymerase II transcription. Although RNA polymerase binds the TATA box on the promoter DNA, no initiation of transcription occurs until TFIIH is bound to the PIC. TFIIH is the only factor with known enzymatic activities.

Literature References
PubMed ID Title Journal Year
8946909 The general transcription factors of RNA polymerase II.

Orphanides, G, Lagrange, T, Reinberg, D

Genes Dev 1997
Participants
Participant Of
Orthologous Events
Authored
Created