deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)

Stable Identifier
R-HSA-109671
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic deoxycytidine kinase (DCK) catalyzes the reactions of deoxyadenosine and deoxyguanosine with ATP to form the corresponding nucleotide monophosphates and AMP, The enzyme is a dimer (Bohman and Eriksson 1988; Datta et al. 1989). While the enzyme can be found in nuclei of cultured cells expressing high levels of a tagged recombinant protein, its normal location appears to be cytosolic (Hatzis et al. 1998).

Literature References
PubMed ID Title Journal Year
9804782 The intracellular localization of deoxycytidine kinase

Hatzis, P, Al-Madhoon, AS, Jullig, M, Petrakis, TG, Eriksson, S, Talianidis, I

J Biol Chem 1998
2844225 Deoxycytidine kinase from human leukemic spleen: preparation and characterization of the homogeneous enzyme

Bohman, C, Eriksson, S

Biochemistry 1988
2539852 Human T-lymphoblast deoxycytidine kinase: purification and properties

Datta, NS, Shewach, DS, Hurley, MC, Mitchell, BS, Fox, IH

Biochemistry 1989
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
nucleoside kinase activity of DCK dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Created