GRB2-1 binds SOS1

Stable Identifier
R-HSA-109813
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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In the cytoplasm of unstimulated cells, SOS1 is found in a complex with GRB2. The interaction occurs between the carboxy terminal domain of SOS1 and the Src homology 3 (SH3) domains of GRB2.

Literature References
PubMed ID Title Journal Year
8479541 Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling.

Li, N, Batzer, A, Daly, R, Yajnik, V, Skolnik, E, Margolis, B, Schlessinger, J

Nature 1993
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