p-T185,Y187-MAPK1 [cytosol]

Stable Identifier
R-HSA-109853
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
p-T185,Y187-ERK2, Mitogen-activated protein kinase 1(phosphorylated), Extracellular signal-regulated kinase 2 phosphorylated, Mitogen-activated protein kinase 2, p-T185,Y187-MAPK 2, MAP kinase 2 phosphorylated, p42-MAPK phosphorylated, ERT1 phosphorylated, phospho-ERK-2
p-T185,Y187-MAPK1 [cytosol] icon
Locations in the PathwayBrowser
External Reference Information
External Reference
Gene Names
MAPK1, ERK2, PRKM1, PRKM2
Chain
initiator methionine:1, chain:2-360
Other Identifiers
0000580471
0002850739
0003990647
11715841_at
11715842_a_at
11715843_at
11738871_a_at
11738872_x_at
11751223_a_at
11751224_x_at
11753379_a_at
1552263_at
1552264_a_at
16932831
208351_s_at
212271_at
224621_at
3954239
3954240
3954241
3954242
3954243
3954244
3954245
3954246
3954247
3954248
3954249
3954252
3954256
3954257
3954261
3954262
3954264
3954266
3954273
3954274
45715_at
55528_at
5594
8074791
976_s_at
A_23_P257895
A_24_P237265
GE476071
GE534117
GE56878
GE86009
GO:0000003
GO:0000165
GO:0000166
GO:0000186
GO:0000187
GO:0000902
GO:0001784
GO:0002376
GO:0003674
GO:0003677
GO:0003690
GO:0004672
GO:0004674
GO:0004707
GO:0004708
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005764
GO:0005768
GO:0005769
GO:0005770
GO:0005773
GO:0005794
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005886
GO:0005901
GO:0005925
GO:0006259
GO:0006412
GO:0006464
GO:0006468
GO:0006810
GO:0006913
GO:0006915
GO:0006935
GO:0006950
GO:0006974
GO:0007010
GO:0007049
GO:0007165
GO:0007166
GO:0007267
GO:0007268
GO:0007411
GO:0007507
GO:0007568
GO:0007611
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008353
GO:0008543
GO:0009058
GO:0009636
GO:0009790
GO:0009887
GO:0010468
GO:0010628
GO:0010800
GO:0014032
GO:0014066
GO:0014069
GO:0015031
GO:0015966
GO:0016020
GO:0016032
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0018107
GO:0019233
GO:0019858
GO:0019899
GO:0019901
GO:0019902
GO:0030154
GO:0030168
GO:0030278
GO:0030335
GO:0030424
GO:0030641
GO:0030878
GO:0031143
GO:0031410
GO:0031435
GO:0031647
GO:0031663
GO:0032212
GO:0032496
GO:0032839
GO:0032872
GO:0032991
GO:0033598
GO:0034198
GO:0034614
GO:0034641
GO:0035094
GO:0035556
GO:0035578
GO:0038095
GO:0038096
GO:0038127
GO:0040007
GO:0040011
GO:0042307
GO:0042473
GO:0042592
GO:0042802
GO:0043167
GO:0043204
GO:0043226
GO:0043312
GO:0043330
GO:0043627
GO:0044281
GO:0044403
GO:0045596
GO:0045727
GO:0045893
GO:0046697
GO:0048538
GO:0048646
GO:0048856
GO:0048870
GO:0050852
GO:0050853
GO:0050877
GO:0051090
GO:0051276
GO:0051403
GO:0051493
GO:0051973
GO:0060020
GO:0060045
GO:0060291
GO:0060324
GO:0060425
GO:0060440
GO:0060716
GO:0061308
GO:0070371
GO:0070849
GO:0071276
GO:0071310
GO:0071356
GO:0072584
GO:0072686
GO:0090170
GO:0097011
GO:1900034
GO:1903351
GO:1904355
GO:1904813
GO:2000641
Hs.324473.2.S1_3p_at
Hs.66151.0.S1_3p_at
Hs2.324473.2.S1_3p_at
ILMN_1665276
ILMN_1706677
ILMN_1767320
ILMN_2235283
PH_hs_0016141
PH_hs_0039033
TC22000547.hg
Z11695_at
g4506086_3p_a_at
Participant Of
Other forms of this molecule
Inferred To
Modified Residues
Name
O-phospho-L-threonine at 185
Coordinate
185
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O4'-phospho-L-tyrosine at 187
Coordinate
187
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
ZINC - Investigational
ZINC - Metabolites
IntEnz
GeneCards
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (47)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P35236 PTPN7  2 0.775 6
 UniProt:P51812 RPS6KA3  7 0.752 5
 UniProt:Q13115 DUSP4  1 0.75 5
 UniProt:Q15349 RPS6KA2  7 0.742 8
 UniProt:Q9BUB5 MKNK1  1 0.697 9
 UniProt:Q15121 PEA15  1 0.675 4
 UniProt:P27361 MAPK3  6 0.669 5
 UniProt:Q15418 RPS6KA1  7 0.669 5
 UniProt:Q9BRK4 LZTS2      0.666 4
 UniProt:Q16539-3 MAPK14      0.656 5
 UniProt:P14921 ETS1  2 0.641 3
 UniProt:P02687 MBP      0.623 2
 UniProt:Q15256 PTPRR      0.621 3
 UniProt:P29353-2 SHC1  6 0.618 4
 UniProt:P35813 PPM1A  2 0.611 19
 UniProt:P28482 MAPK1  18 0.609 3
 UniProt:Q02750 MAP2K1  27 0.609 2
 UniProt:Q9Y296 TRAPPC4  2 0.581 3
 UniProt:Q12913 PTPRJ  2 0.578 7
 UniProt:Q16828 DUSP6  2 0.564 3
 UniProt:P32121 ARRB2  2 0.564 3
 UniProt:Q05922  1 0.558 2
 UniProt:P62487 POLR2G  1 0.556 3
 UniProt:Q6NYC8 PPR18      0.556 3
 UniProt:O76064 RNF8  1 0.556 3
 UniProt:Q99750 MDFI      0.556 3
 UniProt:A0A384NQ31 A0A384NQ31      0.556 3
 UniProt:A2A3K4 PTPC1      0.556 3
 UniProt:Q15256-5 PTPRR      0.556 3
 UniProt:P61764 STXBP1  2 0.556 3
 UniProt:P15882 CHN1  1 0.556 3
 UniProt:Q9UPG8 PLAL2      0.556 3
 UniProt:P25786 PSMA1  2 0.556 3
 UniProt:Q08117-2 TLE5      0.556 3
 IntAct:EBI-16436244 CCSB ORF ID      0.556 3
 UniProt:B2RXF5 ZBT42      0.556 3
 UniProt:P35548 MSX2  1 0.556 3
 UniProt:Q99956 DUSP9  1 0.547 3
 UniProt:P28562 DUSP1  1 0.544 3
 UniProt:Q7L5N1 COPS6  2 0.544 2
 UniProt:Q16690 DUSP5  1 0.543 3
 UniProt:Q9U1H0 CIC      0.527 2
 UniProt:P06239 LCK  4 0.524 2
 UniProt:P53004 BLVRA  1 0.499 2
 UniProt:Q15025 TNIP1  1 0.488 2
 UniProt:P10415 BCL2  1 0.488 2
 UniProt:P46531 NOTCH1  60 0.462 2
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