MAP2K2 phosphorylates MAPK1

Stable Identifier
R-HSA-109862
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

MAP2K2 (MEK2) phosphorylates MAPK1 (ERK2). Phosphorylation of MAPK1 activates its kinase activity.

Literature References
PubMed ID Title Journal Year
8388392 Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.

Zheng, CF, Guan, KL

J Biol Chem 1993
22177953 MEK1/2 dual-specificity protein kinases: structure and regulation

Roskoski, R Jr

Biochem. Biophys. Res. Commun. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S,T-MAP2K2:MAPK1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed