Reactome: A Curated Pathway Database

cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]

Stable Identifier
R-HSA-109903
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cytosolic uridine-cytidine kinase 2 (UCK2) catalyzes the reactions of cytidine or uridine with ATP to form CMP or UMP and ADP (Greenberg et al. 1977; Van Rompay et al. 2001). Crystallographic data show the enzyme to be a tetramer (Suzuki et al. 2004). When it is expressed as a fusion construct with green fluorescent protein, the protein localizes primarily to the cytosol of transfected CHO cells (Van Rompay et al. 2003).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
nucleoside kinase activity of UCK2 tetramer [cytosol] UCK2 tetramer [cytosol] nucleoside kinase activity (0019206)
Orthologous Events