cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]

Stable Identifier
R-HSA-109903
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic uridine-cytidine kinase 2 (UCK2) catalyzes the reactions of cytidine or uridine with ATP to form CMP or UMP and ADP (Greenberg et al. 1977; Van Rompay et al. 2001). Crystallographic data show the enzyme to be a tetramer (Suzuki et al. 2004). When it is expressed as a fusion construct with green fluorescent protein, the protein localizes primarily to the cytosol of transfected CHO cells (Van Rompay et al. 2003).

Literature References
PubMed ID Title Journal Year
14609716 Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases

Van Rompay, AR, Johansson, M, Karlsson, A

Pharmacol Ther 2003
195585 Uridine kinase activities and pyrimidine nucleoside phosphorylation in fluoropyrimidine-sensitive and -resistant cell lines of the Novikoff hepatoma

Greenberg, N, Schumm, DE, Webb, TE

Biochem J 1977
15130468 Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase

Suzuki, NN, Koizumi, K, Fukushima, M, Matsuda, A, Inagaki, F

Structure 2004
11306702 Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases

Van Rompay, AR, Norda, A, Linden, K, Johansson, M, Karlsson, A

Mol Pharmacol 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
nucleoside kinase activity of UCK2 tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
Created