AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs

Stable Identifier
R-HSA-110138
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
(d)AMP or (d)CMP + ATP <=> (d)ADP or (d)CDP + ADP [AK5]
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Adenylate kinases (AKs) are nucleoside monophosphate kinases, which catalyze the phosphorylation of AMP by using ATP or GTP as phosphate donors. AKs are thus involved in maintaining the homeostasis of cellular nucleotides. CMP, dCMP and dAMP are other substrates phosphorylated with less efficiency by AKs. Cytosolic adenylate kinases 5, 7, 8 and 9 (AK5, 7, 8 and 9) catalyze the reversible phosphorylation of (d)AMP and (d)CMP with ATP to form (d)ADP and (d)CDP, respectively, and ADP. When GTP is the phosphate donor, only AMP and CMP are efficiently phosphorylated (Panayiotou et al. 2011, Amiri et al. 2013). In the body AK5 expression was observed only in brain of nine tissues tested by Northern blotting (Van Rompay et al. 1999). AK5 is inferred to occur as a dimer from unpublished crystallographic data obtained for the catalytically active carboxyterminal third of the protein (PDB 2BWJ).

Literature References
PubMed ID Title Journal Year
10215863 Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein

Van Rompay, AR, Johansson, M, Karlsson, A

Eur J Biochem 1999
23416111 The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase

Amiri, M, Conserva, F, Panayiotou, C, Karlsson, A, Solaroli, N

Int. J. Biochem. Cell Biol. 2013
21080915 The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes

Panayiotou, C, Solaroli, N, Xu, Y, Johansson, M, Karlsson, A

Biochem. J. 2011
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
nucleoside kinase activity of AK5,7,8,9 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Created
Cite Us!