TDG glycosylase mediated recognition and binding of a thymine opposite to a guanine

Stable Identifier
R-HSA-110158
Type
Reaction
Species
Homo sapiens
Compartment
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TDG is a G/T mismatch-specific thymine DNA glycosylase that recognizes and binds thymine mispaired with guanine. G:T mispairs occur when 5-methylcytosine deaminates into thymine. Besides being mutagenic, conversion of 5-methylcytosine into thymine may also affect gene expression by changing the DNA methylation pattern. TDG shows a preference for G:T mispairs in CpG islands (Neddermann and Jiricny 1993, Neddermann et al. 1996). TDG ortholog knockout is embryonic lethal in mice, where it is implicated in protection of CpG islands from hypermethylation and active demethylation of tissue-specific developmentally and homornally regulated promoters and enhancers (Cortellino et al. 2011).

Literature References
PubMed ID Title Journal Year
8407958 The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells

Neddermann, P, Jiricny, J

J. Biol. Chem. 1993
21722948 Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

Cortellino, S, Xu, J, Sannai, M, Moore, R, Caretti, E, Cigliano, A, Le Coz, M, Devarajan, K, Wessels, A, Soprano, D, Abramowitz, LK, Bartolomei, MS, Rambow, F, Bassi, MR, Bruno, T, Fanciulli, M, Renner, C, Klein-Szanto, AJ, Matsumoto, Y, Kobi, D, Davidson, I, Alberti, C, Larue, L, Bellacosa, A

Cell 2011
8662714 Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase

Neddermann, P, Gallinari, P, Lettieri, T, Schmid, D, Truong, O, Hsuan, JJ, Wiebauer, K, Jiricny, J

J. Biol. Chem. 1996
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