TDG glycosylase mediated recognition and binding of an uracil opposite to a guanine

Stable Identifier
R-HSA-110159
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

TDG, a G/T mismatch-specific thymine DNA glycosylase, recognizes and binds uracil mispaired with guanine. G:U mispairs occur after cytosine undergoes spontaneous deamination and converts to uracil (Neddermann and Jiricny 1993, Hashimoto et al. 2012).

Literature References
PubMed ID Title Journal Year
22962365 Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation

Hashimoto, H, Hong, S, Bhagwat, AS, Zhang, X, Cheng, X

Nucleic Acids Res. 2012
8407958 The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells

Neddermann, P, Jiricny, J

J. Biol. Chem. 1993
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