TDG glycosylase mediated recognition and binding of an uracil opposite to a guanine

Stable Identifier
R-HSA-110159
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

TDG, a G/T mismatch-specific thymine DNA glycosylase, recognizes and binds uracil mispaired with guanine. G:U mispairs occur after cytosine undergoes spontaneous deamination and converts to uracil (Neddermann and Jiricny 1993, Hashimoto et al. 2012).

Participants
Participant Of