TDG glycosylase mediated recognition and binding of an ethenocytosine

Stable Identifier
R-HSA-110210
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
TDG, a G/T mismatch-specific DNA glycosylase, recognizes and binds ethenocytosine paired with guanine. Ethenocytosine is an etheno-adduct of cytosine, generated by peroxidation of the cytosine ring (Hang et al. 1998).
Literature References
PubMed ID Title Journal Year
9811839 A 55-kDa protein isolated from human cells shows DNA glycosylase activity toward 3,N4-ethenocytosine and the G/T mismatch

Singer, B, Hang, B, Fraenkel-Conrat, H, Medina, M

Proc. Natl. Acad. Sci. U.S.A. 1998
Participants
Participates
Authored
Reviewed
Created
Cite Us!