TDG glycosylase mediated recognition and binding of an ethenocytosine

Stable Identifier
R-HSA-110210
Type
Reaction
Species
Homo sapiens
Compartment
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TDG, a G/T mismatch-specific DNA glycosylase, recognizes and binds ethenocytosine paired with guanine. Ethenocytosine is an etheno-adduct of cytosine, generated by peroxidation of the cytosine ring (Hang et al. 1998).

Literature References
PubMed ID Title Journal Year
9811839 A 55-kDa protein isolated from human cells shows DNA glycosylase activity toward 3,N4-ethenocytosine and the G/T mismatch

Hang, B, Medina, M, Fraenkel-Conrat, H, Singer, B

Proc. Natl. Acad. Sci. U.S.A. 1998
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