Cleavage of thymine by TDG glycosylase

Stable Identifier
R-HSA-110219
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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TDG, a G/T mismatch-specific thymine DNA glycosylase, cleaves thymine, generated through 5-methylcytosine deamination and mispaired with guanine, from the DNA sugar-phosphate backbone, leaving an apurinic/apyrimidinic (AP) site (Neddermann and Jiricny 1993, Neddermann et al. 1996).

Literature References
PubMed ID Title Journal Year
8662714 Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase

Neddermann, P, Gallinari, P, Lettieri, T, Schmid, D, Truong, O, Hsuan, JJ, Wiebauer, K, Jiricny, J

J. Biol. Chem. 1996
8407958 The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells

Neddermann, P, Jiricny, J

J. Biol. Chem. 1993
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
DNA N-glycosylase activity of TDG:(T:G)-dsDNA [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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