Reactome | Cleavage of thymine glycol by NTHL1 glycosylase

Cleavage of thymine glycol by NTHL1 glycosylase

Stable Identifier

R-HSA-110224

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Cleavage of thymine glycol by NTHL1 glycosylase

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NTHL1 (hNTH1; endonuclease III-like protein 1) cleaves oxidized thymine in the form of thymine glycol from DNA sugar-phosphate backbone and acts as a beta lyase to cleave the DNA sugar-phosphate backbone 5' to the apurinic/apyrimidinic (AP) site generated in the glycolysis step (Ikeda et al. 1998, Dizdaroglu et al. 1999, Miyabe et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
9705289	Purification and characterization of human NTH1, a homolog of Escherichia coli endonuclease III. Direct identification of Lys-212 as the active nucleophilic residue Ikeda, S, Biswas, T, Roy, R, Izumi, T, Boldogh, I, Kurosky, A, Sarker, AH, Seki, S, Mitra, S	J. Biol. Chem.	1998
12140329	Identification of 5-formyluracil DNA glycosylase activity of human hNTH1 protein Miyabe, I, Zhang, QM, Kino, K, Sugiyama, H, Takao, M, Yasui, A, Yonei, S	Nucleic Acids Res.	2002
9890904	Excision of products of oxidative DNA base damage by human NTH1 protein Dizdaroglu, M, Karahalil, B, Sentürker, S, Buckley, TJ, Roldán-Arjona, T	Biochemistry	1999