Cleavage of dihydrouracil by NTHL1 glycosylase

Stable Identifier
R-HSA-110227
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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NTHL1 (hNTH1; endonuclease III-like protein 1) acts as a DNA glycosylase to cleave 5,6-dihydrouracil, formed by deamination of cytosine with partial saturation of the pyrimidine ring (Dizdaroglu et al. 1993), from the DNA sugar-phosphate backbone, and leaves an apurinic/apyrimidinic (AP) site. After the AP site is created, NTHL1 acts as a beta lyase to cleave the DNA strand 5' to the AP site (Ikeda et al. 1998).
Literature References
Participants
Participates
Catalyst Activity

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity of NTHL1:DHU-dsDNA [nucleoplasm]

Orthologous Events
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Reviewed
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