Reactome | Excision of 8-oxoguanine by OGG1 glycosylase

Excision of 8-oxoguanine by OGG1 glycosylase

Stable Identifier

R-HSA-110243

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Excision of 8-oxoguanine by OGG1 glycosylase

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

OGG1 acts as an N-glycosylase and a DNA beta-lyase to excise 8-oxoguanine (8oxoG) from dsDNA, creating an apurinic/apyrimidinic (AP) site, and to nick the DNA sugar-phosphate backbone 5' to the AP site, creating a single strand break (SSB) (Aburatani et al. 1997, Rosenquist et al. 1997, Roldan-Arjona et al. 1997, Radicella et al. 1997, Bjoras et al. 1997, Bruner et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
9223306	Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase Anselmino, C, Wei, YF, Wang, RP, Augustus, M, Lindahl, T, Carter, KC, Klungland, A, Roldán-Arjona, T	Proc. Natl. Acad. Sci. U.S.A.	1997
9321410	Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites Luna, L, Hoff, E, Bjorâs, M, Johnsen, B, Haug, T, Rognes, T, Seeberg, E	EMBO J.	1997
9207108	Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase Zharkov, DO, Grollman, AP, Rosenquist, TA	Proc. Natl. Acad. Sci. U.S.A.	1997
9223305	Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae Desmaze, C, Radicella, JP, Boiteux, S, Fox, MS, Dherin, C	Proc. Natl. Acad. Sci. U.S.A.	1997
10706276	Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA Bruner, SD, Verdine, GL, Norman, DP	Nature	2000
9187114	Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue Yamamoto, K, Takao, M, Yasui, A, Asano, M, Ishida, T, Takashima, R, Kodama, T, Hippo, Y, Aburatani, H, Matsuba, C	Cancer Res.	1997