Reactome | Excision of FapyG by OGG1 glycosylase

Excision of FapyG by OGG1 glycosylase

Stable Identifier

R-HSA-110244

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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OGG1 acts as an N-glycosylase and a DNA beta-lyase to excise 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG), a one electron reduction product of guanine, from the DNA and to nickk the sugar-phosphate backbone 5' to the created apurinic/apyrimidinic (AP) site (Hu et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
16221681	Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes Hu, J, de Souza-Pinto, NC, Haraguchi, K, Hogue, BA, Jaruga, P, Greenberg, MM, Dizdaroglu, M, Bohr, VA	J. Biol. Chem.	2005