Reactome | Cleavage of adenine mispaired with 8-oxoguanine by MUTYH

Cleavage of adenine mispaired with 8-oxoguanine by MUTYH

Stable Identifier

R-HSA-110246

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Cleavage of adenine mispaired with 8-oxoguanine by MUTYH

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MUTYH (MYH) functions as an adenine DNA glycosylase and removes adenines and 2-hydroxyadenines on the newly synthesized DNA strand mispaired with guanines or 8-oxoguanines on the template strand (Ohtsubo et al. 2000, Boldogh et al. 2001). Under physiological conditions, the preferred substrate for both MUTYH isoforms, MUTYH-3 (alpha-3) and MUTYH-6 (gamma-3) is adenine mispaired with 8-oxoguanine (OGUA:Ade) (Shinmura et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
11121482	Adenine excisional repair function of MYH protein on the adenine:8-hydroxyguanine base pair in double-stranded DNA Yokota, J, Takeuchi-Sasaki, M, Saitoh, T, Shinmura, K, Nohmi, T, Kim, SR, Yamaguchi, S	Nucleic Acids Res.	2000
11433026	hMYH cell cycle-dependent expression, subcellular localization and association with replication foci: evidence suggesting replication-coupled repair of adenine:8-oxoguanine mispairs Bassett, H, Milligan, D, Lee, MS, McCullough, AK, Lloyd, RS, Boldogh, I	Nucleic Acids Res.	2001
10684930	Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria Nishioka, K, Fujiwara, T, Shimokawa, H, Oda, H, Iwai, S, Ohtsubo, T, Imaiso, Y, Nakabeppu, Y	Nucleic Acids Res.	2000