Translesion Synthesis by POLH

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

DNA polymerase eta (POLH) consists of 713 amino acids and can bypass thymidine-thymidine dimers, correctly adding two dAMPs opposite to the lesion. Mutations in the POLH gene result in the loss of this bypass activity and account for the XP variant phenotype (XPV) in human xeroderma pigmentosum disorder patients. POLH can carry out TLS past various UV and chemically induced lesions via two steps: (a) preferential incorporation of correct bases opposite to the lesion (b) conditional elongation only at the sites where such correct bases are inserted (Masutani et al. 1999, Masutani et al. 2000).

Literature References
PubMed ID Title Journal Year
10856253 Mechanisms of accurate translesion synthesis by human DNA polymerase eta.

Masutani, C, Kusumoto, R, Iwai, S, Hanaoka, F

EMBO J 2000
10369688 Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity.

Masutani, C, Araki, M, Yamada, A, Kusumoto, R, Nogimori, T, Maekawa, T, Iwai, S, Hanaoka, F

EMBO J 1999
Participant Of
Event Information
Orthologous Events
Cross References
BioModels Database