Formation of Pol zeta complex

Stable Identifier
R-HSA-110322
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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REV3L (hREV3), the catalytic subunit of DNA polymerase zeta (POLZ) belonging to B family of DNA polymerases, binds the adapter protein MAD2L2 (hREV7) to form a functional POLZ complex (Murakamo et al. 2000, Murakamo et al. 2001, Hara et al. 2010).

Literature References
PubMed ID Title Journal Year
10660610 A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2

Murakumo, Y, Roth, T, Ishii, H, Rasio, D, Numata, S, Croce, CM, Fishel, R

J. Biol. Chem. 2000
11485998 Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7

Murakumo, Y, Ogura, Y, Ishii, H, Numata, S, Ichihara, M, Croce, CM, Fishel, R, Takahashi, M

J. Biol. Chem. 2001
20164194 Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1

Hara, K, Hashimoto, H, Murakumo, Y, Kobayashi, S, Kogame, T, Unzai, S, Akashi, S, Takeda, S, Shimizu, T, Sato, M

J. Biol. Chem. 2010
Participants
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Created