Displacement of UNG glycosylase by APEX1 at the AP site

Stable Identifier
R-HSA-110349
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site lyase, displaces UNG from the AP site generated by UNG DNA glycosylase activity (Nicholl et al. 1997, Parikh et al. 1998, Akbari et al. 2004, Kuznetsova et al. 2014).

Literature References
PubMed ID Title Journal Year
9724657 Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA

Parikh, SS, Mol, CD, Slupphaug, G, Bharati, S, Krokan, HE, Tainer, JA

EMBO J 1998
25086253 Pre-steady-state fluorescence analysis of damaged DNA transfer from human DNA glycosylases to AP endonuclease APE1

Kuznetsova, AA, Kuznetsov, NA, Ishchenko, AA, Saparbaev, MK, Fedorova, OS

Biochim. Biophys. Acta 2014
15479784 Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells

Akbari, M, Otterlei, M, Peņa-Diaz, J, Aas, PA, Kavli, B, Liabakk, NB, Hagen, L, Imai, K, Durandy, A, Slupphaug, G, Krokan, HE

Nucleic Acids Res. 2004
9200707 Reconstitution of human base excision repair with purified proteins

Nicholl, ID, Nealon, K, Kenny, MK

Biochemistry 1997
Participants
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