Displacement of TDG glycosylase by APEX1 at the AP site

Stable Identifier
R-HSA-110350
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site lyase, displaces TDG from the AP site created by the DNA glycosylase activity of TDG. In the absence of APEX1, TDG remains tightly bound to the AP site, which inhibits subsequent steps in the base excision repair. Sumoylation of TDG may also be involved in the APEX1-mediated displacement of TDG from AP sites (Hardeland et al. 2002, Steinacher and Schar 2005, Fitzgerald and Drohat 2008).

Participants
Participant Of
Orthologous Events
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Created