Displacement of SMUG1 glycosylase by APEX1 at the AP site

Stable Identifier
R-HSA-110351
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site lyase, displaces SMUG1 from the AP site created by the SMUG1 DNA glycosylase activity (Pettersen et al. 2007).

Literature References
PubMed ID Title Journal Year
17537817 Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms

Pettersen, HS, Sundheim, O, Gilljam, KM, Slupphaug, G, Krokan, HE, Kavli, B

Nucleic Acids Res. 2007
Participants
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Orthologous Events
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