Displacement of MBD4 glycosylase by APEX1 at the AP site

Stable Identifier
R-HSA-110353
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site lyase, displaces MBD4 (MED1) from the AP site generated by the MBD4 DNA glycosylase activity (Kuznetsova et al. 2014).

Literature References
PubMed ID Title Journal Year
25086253 Pre-steady-state fluorescence analysis of damaged DNA transfer from human DNA glycosylases to AP endonuclease APE1

Kuznetsova, AA, Kuznetsov, NA, Ishchenko, AA, Saparbaev, MK, Fedorova, OS

Biochim. Biophys. Acta 2014
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Orthologous Events
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