Displacement of OGG1 glycosylase by APEX1 at the AP site

Stable Identifier
R-HSA-110354
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site lyase, displaces OGG1 from the AP site generated by the OGG1 DNA glycosylase activity, thus allowing for the base excision repair to proceed (Hill et al. 2001, Kuznetsova et al. 2014).

Literature References
PubMed ID Title Journal Year
11139613 Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repair

Hill, JW, Hazra, TK, Izumi, T, Mitra, S

Nucleic Acids Res. 2001
25086253 Pre-steady-state fluorescence analysis of damaged DNA transfer from human DNA glycosylases to AP endonuclease APE1

Kuznetsova, AA, Kuznetsov, NA, Ishchenko, AA, Saparbaev, MK, Fedorova, OS

Biochim. Biophys. Acta 2014
Participants
Participant Of
Orthologous Events
Authored
Reviewed