Displacement of MUTYH glycosylase by APEX1 at the AP site

Stable Identifier
R-HSA-110355
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic site lyase, displaces MUTYH (MYH) from the AP site generated by the MUTYH DNA glycosylase activity, thus increasing MUTYH turnover and overall glycosylase efficiency, and allowing for the base excision repair to proceed (Yang et al. 2001).

Literature References
PubMed ID Title Journal Year
11160897 Enhanced activity of adenine-DNA glycosylase (Myh) by apurinic/apyrimidinic endonuclease (Ape1) in mammalian base excision repair of an A/GO mismatch

Yang, H, Clendenin, WM, Wong, D, Demple, B, Slupska, MM, Chiang, JH, Miller, JH

Nucleic Acids Res. 2001
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created