Displacement of MPG glycosylase by APEX1 at the AP site

Stable Identifier
R-HSA-110356
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site lyase, displaces MPG from the AP site generated by the MPG DNA glycosylase activity, thus increasing MPG turnover and the overall glycosylase efficiency (Xia et al. 2005).

Literature References
PubMed ID Title Journal Year
15713479 Human 3-methyladenine-DNA glycosylase: effect of sequence context on excision, association with PCNA, and stimulation by AP endonuclease

Xia, L, Zheng, L, Lee, HW, Bates, SE, Federico, L, Shen, B, O'Connor, TR

J. Mol. Biol. 2005
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created