Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break

Stable Identifier
R-HSA-110375
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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After incision of the DNA strand 5' to the apurinic/apyrimidinic (AP) site by APEX1 (APE1), POLB (DNA polymerase beta) excises the 5'-terminal abasic deoxyribose phosphate (5'-dRP), thus removing the AP site (Bennet et al. 1997).

Literature References
PubMed ID Title Journal Year
9207062 Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway.

Bennett, RA, Wilson, DM, Wong, D, Demple, B

Proc Natl Acad Sci U S A 1997
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
DNA-(apurinic or apyrimidinic site) endonuclease activity of POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created