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p-Y1034-JAK1 [cytosol]
Stable Identifier
R-HSA-1112543
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p(Y1034)-JAK1, Tyrosine-protein kinase JAK1, JAK1_HUMAN, Janus kinase 1
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-6 family signaling (Homo sapiens)
Interleukin-6 signaling (Homo sapiens)
IL6ST is tyrosine phosphorylated (Homo sapiens)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
JAK activation (Homo sapiens)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
PTPN11 binds CBL (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
PTPN11 binds p-Y759-IL6ST (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
PTPN11 is phosphorylated (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Phosphorylated STATs are released (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
SOCS3 binds IL6ST (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Serine phosphorylation of STATs (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF-independent MAPK1/3 activation (Homo sapiens)
MAPK1 (ERK2) activation (Homo sapiens)
MAP2K2 binds MAPK1 (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
MAPK3 (ERK1) activation (Homo sapiens)
MAP2K1 binds MAPK3 (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1034-JAK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23458 JAK1
Gene Names
JAK1, JAK1A, JAK1B
Chain
chain:1-1154
Reference Genes
BioGPS Gene:3716 JAK1
COSMIC (genes):JAK1 JAK1
CTD Gene:3716 JAK1
dbSNP Gene:3716 JAK1
ENSEMBL:ENSG00000162434 JAK1
HGNC:6190 JAK1
KEGG Gene (Homo sapiens):3716 JAK1
Monarch:3716 JAK1
NCBI Gene:3716 JAK1
OMIM:147795 JAK1
UCSC:P23458 JAK1
Reference Transcript
RefSeq:NM_001321856.1 JAK1
RefSeq:NM_001321854.1 JAK1
RefSeq:NM_001321853.1 JAK1
RefSeq:NM_002227.3 JAK1
RefSeq:NM_001320923.1 JAK1
RefSeq:NM_001321855.1 JAK1
RefSeq:NM_001321852.1 JAK1
Other Identifiers
0006590292
11717685_at
11717686_a_at
11717687_a_at
1457_at
1552610_a_at
1552611_a_at
16688164
16688214
201648_at
2416521
2416523
2416524
2416525
2416526
2416528
2416529
2416530
2416531
2416532
2416534
2416535
2416536
2416537
2416541
2416542
2416544
2416545
2416549
2416553
2416556
2416558
2416559
2416561
2416566
2416568
2416569
2416570
2416593
2416594
2416595
2416709
2416711
34877_at
3716
41594_at
7916747
A_21_P0001139
A_23_P97005
A_24_P410678
A_33_P3784283
GE58033
GO:0000165
GO:0000166
GO:0002376
GO:0003674
GO:0004672
GO:0004713
GO:0004715
GO:0005131
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005768
GO:0005829
GO:0005856
GO:0005925
GO:0006464
GO:0006468
GO:0006950
GO:0007155
GO:0007165
GO:0008150
GO:0012505
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019221
GO:0019899
GO:0019903
GO:0031410
GO:0031625
GO:0031730
GO:0034112
GO:0035556
GO:0035722
GO:0035723
GO:0038110
GO:0038111
GO:0038113
GO:0038114
GO:0043167
GO:0043226
GO:0046677
GO:0046872
GO:0048646
GO:0048856
GO:0060333
GO:0060334
GO:0060337
GO:0070102
GO:0070106
GO:0070757
GO:0150105
GO:1903672
HMNXSV003011048
HMNXSV003020647
Hs.50651.0.S2_3p_at
Hs2.50651.1.S1_3p_s_at
Hs2.50651.1.S2_3p_s_at
ILMN_1793384
M64174_at
PH_hs_0025462
TC01002741.hg
TC01002747.hg
TC01005542.hg
Participates
as a member of
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
Other forms of this molecule
p-Y1022,Y1023-JAK1 [cytosol]
JAK1 [endosome]
p-JAK1 [cytosol]
JAK1 [cytosol]
p-Y-JAK1 [cytosol]
Inferred To
phospho-jak1 [cytosol]
(Danio rerio)
phospho-JAK1 [cytosol]
(Bos taurus)
phospho-JAK1 [cytosol]
(Canis familiaris)
phospho-JAK1 [cytosol]
(Gallus gallus)
phospho-Jak1 [cytosol]
(Mus musculus)
phospho-Jak1 [cytosol]
(Rattus norvegicus)
Modified Residues
Name
O4'-phospho-L-tyrosine at 1034
Coordinate
1034
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001307852.1
,
NP_001308782.1
,
NP_001308783.1
,
NP_001308781.1
,
NP_001308785.1
,
NP_001308784.1
,
NP_002218.2
ZINC - World Drugs
JAK1_HUMAN
OpenTargets
ENSG00000162434
ZINC - FDA approved
JAK1_HUMAN
ZINC - Substances
JAK1_HUMAN
ZINC target
P23458
ZINC - Biogenic
JAK1_HUMAN
PRO
P23458
PDB
3EYH
,
6C7Y
,
6N7B
,
5HX8
,
4E4N
,
6HZU
,
6AAH
,
6BBU
,
4IVC
,
6N7C
,
6GGH
,
4EHZ
,
6DBN
,
4IVD
,
6N7D
,
6TPE
,
4K6Z
,
4GS0
,
4I5C
,
6N77
,
6ELR
,
5L04
,
4IVB
,
4E5W
,
6N78
,
5E1E
,
3EYG
,
6RSE
,
6SM8
,
6N79
,
5WO4
,
6RSB
,
6RSH
,
4L00
,
4EI4
,
5KHW
,
6W8L
,
5IXD
,
6RSC
,
4FK6
,
4L01
,
5IXI
,
6SMB
,
6TPF
,
4E4L
,
4K77
,
6N7A
,
5KHX
,
6RSD
ZINC - Investigational
JAK1_HUMAN
HPA
ENSG00000162434-JAK1
GeneCards
P23458
Ensembl
ENST00000342505
,
ENSP00000499900
,
ENSP00000500296
,
ENSP00000343204
,
ENSP00000500485
,
ENSG00000162434
,
ENST00000672434
,
ENST00000672179
,
ENST00000672247
,
ENSP00000500841
,
ENST00000671954
,
ENST00000671929
,
ENSP00000499884
ZINC - Predictions - Purchasable
JAK1_HUMAN
HMDB Protein
HMDBP01309
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48551 IFNAR2
0.591
3
UniProt:P40763 STAT3
10
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.564
2
UniProt:P40189-1 IL6ST
1
p-5Y-IL6ST-1 [plasma membrane]
(R-HSA-1112580)
0.556
3
UniProt:O75886 STAM2
2
STAM2 [cytosol]
(R-HSA-182965)
Ub-STAM2 [cytosol]
(R-HSA-6782781)
0.502
2
UniProt:O60674 JAK2
8
p-JAK2 [cytosol]
(R-HSA-210621)
p-Y1007,Y1008-JAK2 [cytosol]
(R-HSA-9005327)
p-Y813-JAK2 [cytosol]
(R-HSA-997248)
JAK2 V617F [nucleoplasm]
(R-HSA-5211269)
JAK2 [endosome lumen]
(R-HSA-2002372)
p-12Y-JAK2 [cytosol]
(R-HSA-2586516)
JAK2 [cytosol]
(R-HSA-210620)
p-Y1007-JAK2 [cytosol]
(R-HSA-873799)
0.463
4
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