Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
p-Y1054-TYK2 [cytosol]
Stable Identifier
R-HSA-1112598
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p(Y1054)-TYK2, Non-receptor tyrosine-protein kinase TYK2, TYK2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-6 family signaling (Homo sapiens)
Interleukin-6 signaling (Homo sapiens)
IL6ST is tyrosine phosphorylated (Homo sapiens)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
JAK activation (Homo sapiens)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
PTPN11 binds CBL (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
PTPN11 binds p-Y759-IL6ST (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
PTPN11 is phosphorylated (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
Phosphorylated STATs are released (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
SOCS3 binds IL6ST (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
Serine phosphorylation of STATs (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF-independent MAPK1/3 activation (Homo sapiens)
MAPK1 (ERK2) activation (Homo sapiens)
MAP2K2 binds MAPK1 (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
MAPK3 (ERK1) activation (Homo sapiens)
MAP2K1 binds MAPK3 (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Activated JAK1, JAK2, TYK2 [cytosol] (Homo sapiens)
p-Y1054-TYK2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29597 TYK2
Gene Names
TYK2
Chain
chain:1-1187
Reference Genes
BioGPS Gene:7297 TYK2
COSMIC (genes):TYK2 TYK2
CTD Gene:7297 TYK2
dbSNP Gene:7297 TYK2
ENSEMBL:ENSG00000105397 TYK2
HGNC:12440 TYK2
KEGG Gene (Homo sapiens):7297 TYK2
Monarch:7297 TYK2
NCBI Gene:7297 TYK2
OMIM:176941 TYK2
UCSC:P29597 TYK2
Reference Transcript
RefSeq:XM_011528245.1 TYK2
RefSeq:NM_003331.4 TYK2
Other Identifiers
0001980068
11757379_a_at
16868689
205546_s_at
3850280
3850281
3850282
3850284
3850288
3850290
3850292
3850294
3850295
3850296
3850298
3850300
3850301
3850302
3850304
3850307
3850308
3850309
3850310
3850311
3850313
3850314
3850315
3850316
3850317
3850318
3850319
3850320
3850321
3850325
3850326
3850327
3850328
7297
8033996
993_at
A_23_P153311
GE59795
GO:0000166
GO:0002376
GO:0003674
GO:0004672
GO:0004713
GO:0004715
GO:0005131
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0006464
GO:0006468
GO:0006950
GO:0007165
GO:0008150
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019221
GO:0031702
GO:0035556
GO:0035722
GO:0038155
GO:0043167
GO:0043226
GO:0060337
GO:0070062
GO:0070106
ILMN_1676955
PH_hs_0004337
TC19001164.hg
X54637_at
g4507748_3p_a_at
Participant Of
hasCandidate
Activated JAK1, JAK2, TYK2 [cytosol]
Other forms of this molecule
p-TYK2 [cytosol]
p-Y-TYK2 [cytosol]
TYK2 [cytosol]
p-Y1054,Y1055-TYK2 [cytosol]
Inferred To
phospho-TYK2 [cytosol] (Bos taurus)
phospho-TYK2 [cytosol] (Canis familiaris)
phospho-TYK2 [cytosol] (Gallus gallus)
phospho-nasp [cytosol] (Xenopus tropicalis)
phospho-tyk2 [cytosol] (Danio rerio)
phospho-Tyk2 [cytosol] (Mus musculus)
phospho-Tyk2 [cytosol] (Rattus norvegicus)
Modified Residues
Name
O4'-phospho-L-tyrosine at 1054
Coordinate
1054
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_011526547.1
,
NP_003322.3
ZINC - World Drugs
TYK2_HUMAN
OpenTargets
ENSG00000105397
ZINC - FDA approved
TYK2_HUMAN
ZINC - Substances
TYK2_HUMAN
ZINC target
P29597
ZINC - Biogenic
TYK2_HUMAN
PRO
P29597
PDB
4GFO
,
3ZON
,
6NZH
,
4GJ3
,
6VNS
,
3LXP
,
6AAM
,
5F1Z
,
4PO6
,
5WAL
,
6NZE
,
6NZF
,
4GVJ
,
6DBM
,
6NZR
,
3NYX
,
6OVA
,
5C03
,
6VNY
,
5C01
,
4GIH
,
6DBK
,
6NZP
,
4PY1
,
4GJ2
,
6NSL
,
5F20
,
6VNV
,
4WOV
,
4OLI
,
3LXN
,
6VNX
,
5TKD
,
4GII
,
6NZQ
,
3NZ0
ZINC - Investigational
TYK2_HUMAN
IntEnz
2.7.10.2
GeneCards
P29597
HPA
ENSG00000105397-TYK2
Ensembl
ENST00000264818
,
ENSP00000431885
,
ENSP00000264818
,
ENST00000525621
,
ENSG00000105397
ZINC - Predictions - Purchasable
TYK2_HUMAN
Orphanet
17260
HMDB Protein
HMDBP01375
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5VWX1 KHDRBS2
2
p-Y-KHDRBS2 [nucleoplasm]
(R-HSA-8849031)
KHDRBS2 [nucleoplasm]
(R-HSA-8849028)
0.781
7
UniProt:Q13643 FHL3
0.718
6
UniProt:P61978 HNRNPK
2
HNRNPK [nucleoplasm]
(R-HSA-71945)
SUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
0.666
4
UniProt:P17181-1 IFNAR1
0.558
3
UniProt:P61978-2 HNRNPK
0.556
3
UniProt:Q9NQX1-2 PRDM5
0.556
3
UniProt:O75525 KHDRBS3
2
p-Y-KHDRSB3 [nucleoplasm]
(R-HSA-8849035)
KHDRSB3 [nucleoplasm]
(R-HSA-8849040)
0.556
3
UniProt:Q9BUZ4 TRAF4
0.556
3
UniProt:O95994 AGR2
0.556
5
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.556
3
UniProt:A6NEM1 GG6L9
0.556
3
IntAct:EBI-22311199 CCSB ORF ID
0.556
3
UniProt:Q05BL1 Q05BL1
0.556
3
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.556
3
UniProt:Q9ULX6 AKP8L
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:P06463 VE6
0.524
4
UniProt:P04019 VE6
0.524
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.524
2
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text