Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor

Stable Identifier
R-HSA-1112602
Type
Reaction [transition]
Species
Homo sapiens
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Interleukin-6 (IL6) activates the tyrosine phosphorylation of STATs (Akira et al. 1994, Zhong et al. 1994) by receptor-associated JAKs (Hemmann et al. 1996) at a site that is essential for dimerization. For STAT1 this is tyrosine-701, for STAT3 tyrosine-705 (Kaptein et al. 1996, Shuai et al. 1994). Tyrosine phosphorylation leads to homo- or heterodimerization and translocation to the nucleus (Zhong et al. 1994), where the dimers bind to enhancers of IL6- inducible genes e.g. acute phase protein genes, resulting in transcriptional activation.

Literature References
PubMed ID Title Journal Year
8662795 Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation

Hemmann, U, Gerhartz, C, Heesel, B, Sasse, J, Kurapkat, G, Grötzinger, J, Wollmer, A, Zhong, Z, Darnell JE, Jr, Graeve, L, Heinrich, PC, Horn, F

J Biol Chem 1996
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Catalyst Activity
Title
non-membrane spanning protein tyrosine kinase activity of Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane]
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