Activation of BAD and translocation to mitochondria

Stable Identifier
R-HSA-111447
Type
Pathway
Species
Homo sapiens
Compartment
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Summation

The switching on/off of its phosphorylation by growth/survival factors regulates BAD activity. BAD remains sequestered by 14-3-3 scaffold proteins after phosphorylation by Akt1. Calcineurin activates BAD by dephosphorylation.

Literature References
PubMed ID Title Journal Year
15231831 BAD Is a Pro-survival Factor Prior to Activation of Its Pro-apoptotic Function.

Seo, SY, Chen, YB, Ivanovska, I, Ranger, AM, Hong, SJ, Dawson, VL, Korsmeyer, SJ, Bellows, DS, Fannjiang, Y, Hardwick, JM

J Biol Chem 2004
Participants
Participant Of
Event Information
Orthologous Events
Authored
Reviewed