Activation of NOXA and translocation to mitochondria

Stable Identifier
R-HSA-111448
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Activation of NOXA and translocation to mitochondria
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NOXA is transactivated in a p53-dependent manner and by E2F1. Activated NOXA is translocated to mitochondria.
Literature References
PubMed ID Title Journal Year
14684737 Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis

Hershko, T, Ginsberg, D

J Biol Chem 2004
15126337 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53

Hanigan, CL, Robles, AI, Trudel, LJ, Hofseth, LJ, Li, CQ, Wogan, GN, Harris, CC

Cancer Res 2004
Participants
Events
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as an event of
Event Information
Go Biological Process
positive regulation of establishment of protein localization to mitochondrion (1903749)
Orthologous Events
Activation of NOXA and translocation to mitochondria (Bos taurus)
Activation of NOXA and translocation to mitochondria (Canis familiaris)
Activation of NOXA and translocation to mitochondria (Danio rerio)
Activation of NOXA and translocation to mitochondria (Gallus gallus)
Activation of NOXA and translocation to mitochondria (Mus musculus)
Activation of NOXA and translocation to mitochondria (Rattus norvegicus)
Activation of NOXA and translocation to mitochondria (Sus scrofa)
Cross References
BioModels Database
Created
Hardwick, JM  (2004-08-09)
Tsujimoto, Y  (2004-08-09)
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