Release of apoptotic factors from the mitochondria

Stable Identifier
R-HSA-111457
Type
Pathway
Species
Homo sapiens
Compartment
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Apoptotic factors released from the mitochondria promote apoptosis through several different mechanisms. Cytochrome C participates in Apoptosome driven effector caspase activation while SMAC relieves IAP mediated caspase inhibition.

Literature References
PubMed ID Title Journal Year
12660240 Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis.

Song, Z, Yao, X, Wu, M

J Biol Chem 2003
15077149 Toxic proteins released from mitochondria in cell death

Saelens, X, Festjens, N, Vande Walle, L, van Gurp, M, van Loo, G, Vandenabeele, P

Oncogene 2004
12941691 Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization.

Arnoult, D, Gaume, B, Karbowski, M, Sharpe, JC, Cecconi, F, Youle, RJ

EMBO J 2003
10913597 Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis.

Daugas, E, Nochy, D, Ravagnan, L, Loeffler, M, Susin, SA, Zamzami, N, Kroemer, G

FEBS Lett 2000
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database
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Created