Activation of caspases through apoptosome-mediated cleavage

Stable Identifier
R-HSA-111459
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Procaspase-3 and 7 are cleaved by the apoptosome.

Literature References
PubMed ID Title Journal Year
9922454 Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

Slee, EA, Harte, MT, Kluck, RM, Wolf, BB, Casiano, CA, Newmeyer, DD, Wang, HG, Reed, JC, Nicholson, DW, Alnemri, ES, Green, DR, Martin, SJ

J Cell Biol 1999
9390557 Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade.

Li, P, Nijhawan, D, Budihardjo, I, Srinivasula, SM, Alnemri, ES, Wang, X

Cell 1997
Participants
Participant Of
Event Information
Orthologous Events
Cross References
BioModels Database
Authored