Cytochrome c-mediated apoptotic response

Stable Identifier
R-HSA-111461
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

Upon its release from the mitochondrial intermembrane space, cytochrome c (CYSC) binds to and causes an ATP-mediated conformational change in the cytoplasmic adaptor protein apoptotic protease‑activating factor 1 (APAF1). This conformational change triggers the formation of procaspase-9-activating oligomeric protein complex named apoptosome. The active caspase‑9 holoenzyme activates downstream effector caspases‑3 and ‑7. The activated effector caspases then cleave various cellular proteins.

Literature References
PubMed ID Title Journal Year
15184073 Apo cytochrome c inhibits caspases by preventing apoptosome formation

Martin, AG, Nguyen, J, Wells, JA, Fearnhead, HO

Biochem Biophys Res Commun 2004
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created