Apoptotic cleavage of cellular proteins

Stable Identifier
R-HSA-111465
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Apoptotic cell death is achieved by the caspase-mediated cleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adducin, HIP-55, and desmoglein involved in cell adhesion and maintenance of the cytoskeletal architecture. Cleavage of proteins such as APC and CIAP1 can further stimulate apoptosis by produce proapoptotic proteins (reviewed in Fischer et al., 2003. See also Wee et al., 2006 and the CASVM Caspase Substrates Database: http://www.casbase.org/casvm/squery/index.html ).

Literature References
PubMed ID Title Journal Year
12655297 Many cuts to ruin: a comprehensive update of caspase substrates

Fischer, U, Janicke, RU, Schulze-Osthoff, K

Cell Death Differ 2003
17254298 SVM-based prediction of caspase substrate cleavage sites

Wee, LJ, Tan, TW, Ranganathan, S

BMC Bioinformatics 2006
17599937 CASVM: web server for SVM-based prediction of caspase substrates cleavage sites

Wee, LJ, Tan, TW, Ranganathan, S

Bioinformatics 2007
Participants
Participant Of
Orthologous Events
Cross References
Authored
Reviewed