Apoptotic factor-mediated response

Stable Identifier
R-HSA-111471
Type
Pathway
Species
Homo sapiens
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In response to apoptotic signals, mitochondrial proteins are released into the cytosol and activate both caspase-dependent and -independent cell death pathways. Cytochrome c induces apoptosome formation, AIF and endonuclease G function in caspase independent apoptotic nuclear DNA damage. Smac/DIABLO and HtrA2/OMI promote both caspase activation and caspase-independent cytotoxicity (Saelens et al., 2004).

Literature References
PubMed ID Title Journal Year
12042762 IAP proteins: blocking the road to death's door

Salvesen, GS, Duckett, CS

Nat Rev Mol Cell Biol 2002
15077149 Toxic proteins released from mitochondria in cell death

Saelens, X, Festjens, N, Vande Walle, L, van Gurp, M, van Loo, G, Vandenabeele, P

Oncogene 2004
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database
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Created