Reactome: A Curated Pathway Database

IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]

Stable Identifier
R-HSA-111524
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
inosine 5'-monophosphate + L-aspartate + GTP => adenylosuccinate + guanosine 5'-diphosphate + orthophosphate
Locations in the PathwayBrowser
Summation

Two isoforms of adenylosuccinate synthetase, ADSS and ADSSL1, catalyze the reaction of IMP, aspartate, and GTP to form adenylosuccinate, GDP, and orthophosphate (Powell et al. 1992; Sun et al. 2005). ADSS is a homotetramer (unpublished crystallographic data - PDB 2V40) and ADSSL1 is inferred to be a tetramer likewise.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
adenylosuccinate synthase activity of ADSS, ADSSL1 dimers [cytosol] ADSS, ADSSL1 dimers [cytosol] adenylosuccinate synthase activity (0004019)
Orthologous Events
Cross References
Rhea