Reactome | RRM2B [cytosol]

RRM2B [cytosol]

Stable Identifier

R-HSA-111792

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ribonucleotide reductase M2B (TP53 inducible)

Locations in the PathwayBrowser for interactor UniProt:Q7LG56 RRM2B

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Literature References

PubMed ID	Title	Journal	Year
18997010	Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage Pontarin, G, Fijolek, A, Pizzo, P, Ferraro, P, Rampazzo, C, Pozzan, T, Thelander, L, Reichard, PA, Bianchi, V	Proc. Natl. Acad. Sci. U.S.A.	2008

External Reference Information

External Reference

UniProt:Q7LG56 RRM2B

Gene Names

RRM2B, P53R2

Chain

chain:1-351

Reference Genes

BioGPS Gene:50484 RRM2B

COSMIC (genes):RRM2B RRM2B

CTD Gene:50484 RRM2B

dbSNP Gene:50484 RRM2B

ENSEMBL:ENSG00000048392 RRM2B

HGNC:17296 RRM2B

KEGG:hsa:50484 RRM2B

Monarch:50484 RRM2B

NCBI Gene:50484 RRM2B

OMIM:604712 RRM2B

UCSC:Q7LG56 RRM2B

Reference Transcript

Other Identifiers

11736192_at

11736193_a_at

11736194_a_at

11748815_a_at

11753420_a_at

11753752_x_at

11753877_x_at

11754177_a_at

11754178_x_at

17079808

223342_PM_at

223342_at

3147287

3147288

3147289

3147290

3147291

3147292

3147293

3147294

3147295

3147298

3147299

3147300

3147302

3147303

3147304

3147305

3147308

3147310

3147311

3147312

3147313

50484

55656_at

74312_at

75272_at

8152133

84631_at

A_23_P20225

A_33_P3323384

GE53884

GO:0000731

GO:0001822

GO:0003014

GO:0004748

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005971

GO:0006264

GO:0006281

GO:0006974

GO:0006979

GO:0009185

GO:0009200

GO:0009263

GO:0009265

GO:0010971

GO:0014075

GO:0016020

GO:0016491

GO:0042802

GO:0046872

GO:0048856

GO:0055086

GO:0070318

GO:1901135

GO:1901992

GO:1902254

HMNXSV003011881

ILMN_1698231

ILMN_2170595

PH_hs_0026756

TC08001496.hg

g7229085_3p_at

Participates

as a component of

RRM2B dimer [cytosol] (Homo sapiens)

as an output of

TP53 stimulates transcription of RRM2B gene (Homo sapiens)

Inferred To

RnrS [cytosol] (Drosophila melanogaster)

RRM2B [cytosol] (Bos taurus)

RRM2B [cytosol] (Canis familiaris)

RRM2B [cytosol] (Plasmodium falciparum)

RRM2B [cytosol] (Sus scrofa)

Rrm2b [cytosol] (Mus musculus)

Rrm2b [cytosol] (Rattus norvegicus)

Homologues of RRM2B [cytosol] (Plasmodium falciparum)

rnr-2 [cytosol] (Caenorhabditis elegans)

rrm2b [cytosol] (Danio rerio)

rrm2b [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001165949.1, NP_056528.2, NP_001165948.1

Guide to Pharmacology - Targets

2754

OpenTargets

ENSG00000048392

ENSEMBL

ENSP00000430641, ENSP00000429578, ENST00000395912, ENSP00000379248, ENSG00000048392, ENSP00000251810, ENST00000519962, ENST00000522394, ENST00000251810, ENSP00000429140, ENST00000519317

HPA

ENSG00000048392-RRM2B

GeneCards

RRM2B

PRO

Q7LG56

Pharos - Targets

Q7LG56

Orphanet

RRM2B

GlyGen

Q7LG56

PDB

3HF1, 2VUX, 4DJN

HMDB Protein

HMDBP07407

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7LG56 RRM2B	1	RRM2B [cytosol] (R-HSA-111792)	0.668	3
UniProt:O43929 ORC4	1	ORC4 [nucleoplasm] (R-HSA-68519)	0.601	4
UniProt:Q9H4P4 RNF41	1	RNF41 [cytosol] (R-HSA-975977)	0.556	3
UniProt:Q9UM11 FZR1	5	FZR1 [cytosol] (R-HSA-174249) FZR1 [nucleoplasm] (R-HSA-174099) p-FZR1 [nucleoplasm] (R-HSA-174257) p-FZR1 [cytosol] (R-HSA-174193) p-S151-FZR1 [nucleoplasm] (R-HSA-9929805)	0.527	3
UniProt:Q15599 NHRF2			0.527	2
UniProt:P31350 RRM2	1	RRM2 [cytosol] (R-HSA-73639)	0.527	5
UniProt:Q13315 ATM	5	ATM [cytosol] (R-HSA-9665171) ATM [peroxisomal matrix] (R-HSA-9665169) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [nucleoplasm] (R-HSA-69484) Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043)	0.499	3