Hydrolysis of phosphatidylcholine

Stable Identifier
R-HSA-111883
Type
Reaction
Species
Homo sapiens
Compartment
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Once bound to the membrane, cPLA2 hydrolyzes phosphatidylcholine to produce arachidonic acid (AA), a precursor to inflammatory mediators. While several phospholipases can catalyze this reaction in cells overexpressing the enzymes, PLA2G4A is the major enzyme that catalyzes this reaction in vivo (Reed et al. 2011). At the same time, possible physiological roles have been described for soluble phospholipases (sPLA) in the mobilization of arachidonic acid in some cell types or under some physiological conditions (Murakami et al. 2011). Here, the major role of PLA2G4A has been annotated.

Literature References
PubMed ID Title Journal Year
21247147 Functional characterization of mutations in inherited human cPLA? deficiency

Reed, KA, Tucker, DE, Aloulou, A, Adler, D, Ghomashchi, F, Gelb, MH, Leslie, CC, Oates, JA, Boutaud, O

Biochemistry 2011
21746768 Secreted phospholipase A2 revisited

Murakami, M, Taketomi, Y, Sato, H, Yamamoto, K

J. Biochem. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
calcium-dependent phospholipase A2 activity of Active PLA2:phosphatidylcholine [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created