Opioid Signalling

Stable Identifier
Homo sapiens
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Opioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as the enkephalins, the endorphins or the dynorphins. Opioids possess powerful analgesic and sedative effects, and are widely used as pain-killers. Their main side-effect is the rapid establishment of a strong addiction. Opioids receptors are G-protein coupled receptors (GPCR). There are four classes of receptors: mu (MOR), kappa (KOR) and delta (DOR), and the nociceptin receptor (NOP).

Literature References
PubMed ID Title Journal Year
9218123 G proteins and opioid receptor-mediated signalling Cell Signal 1997
16612131 Signal transduction induced by opioids in immune cells: a review Neuroimmunomodulation 2006
9422713 The many faces of G protein signaling J Biol Chem 1998
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