CaMK IV phosphorylates CREB

Stable Identifier
R-HSA-111912
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

The cAMP-responsive element binding protein (CREB), a key regulator of gene expression, is activated by phosphorylation on Ser-133. Several different protein kinases possess the capability of driving this phosphorylation, making it a point of potential convergence for multiple intracellular signaling cascades. Work in neurons has indicated that physiologic synaptic stimulation recruits a fast calmodulin kinase IV (CaMKIV)-dependent pathway that dominates early signaling to CREB.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
calmodulin-dependent protein kinase activity of phospho-CaMK IV:Calmodulin [nucleoplasm]
Physical Entity
Activity
Inferred From
Authored
Reviewed