CaMK IV phosphorylates CREB

Stable Identifier
R-HSA-111912
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

The cAMP-responsive element binding protein (CREB), a key regulator of gene expression, is activated by phosphorylation on Ser-133. Several different protein kinases possess the capability of driving this phosphorylation, making it a point of potential convergence for multiple intracellular signaling cascades. Work in neurons has indicated that physiologic synaptic stimulation recruits a fast calmodulin kinase IV (CaMKIV)-dependent pathway that dominates early signaling to CREB. Activated CaMKIV phosphorylates CREB at S133 thereby initiating the transcription of CREB regulated set of genes leading to protein synthesis and long lasting changes that underlie synaptic plasticity.

Literature References
PubMed ID Title Journal Year
19001277 Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine

Bilbao, A, Parkitna, JR, Engblom, D, Perreau-Lenz, S, Sanchis-Segura, C, Schneider, M, Konopka, W, Westphal, M, Breen, G, Desrivieres, S, Klugmann, M, Guindalini, C, Vallada, H, Laranjeira, R, de Fonseca, FR, Schumann, G, Schütz, G, Spanagel, R

Proc Natl Acad Sci U S A 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
calmodulin-dependent protein kinase activity of phospho-CaMK IV:Calmodulin [nucleoplasm]
Physical Entity
Activity
Inferred From
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Reviewed