CAMK4 autophosphorylates

Stable Identifier
R-HSA-111915
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CAMK4 autophosphorylates
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Autophosphorylation of the N-terminal serine residues, S12 and S13, of CAMK4 is required for full activation after Ca2+/calmodulin binding and phosphorylation of the Ca2+/calmodulin-bound enzyme on threonine residue T200 by a Ca2+/calmodulin-dependent protein kinase kinase (CAMKK1 or CAMKK2) (Chatila et al. 1996).
Literature References
PubMed ID Title Journal Year
8702940 A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR

Ho, N, Anderson, KA, Means, AR, Chatila, T

J Biol Chem 1996
Participants
Input
Output
Participates
as an event of
Catalyst Activity

calmodulin-dependent protein kinase activity of p-T200-CAMK4:CALM1:4xCa2+ [nucleoplasm]

Physical Entity
p-T200-CAMK4:CALM1:4xCa2+ [nucleoplasm] (Homo sapiens)
Activity
calmodulin-dependent protein kinase activity (GO:0004683)
Orthologous Events
CAMK4 autophosphorylates (Bos taurus)
CAMK4 autophosphorylates (Dictyostelium discoideum)
CAMK4 autophosphorylates (Drosophila melanogaster)
CAMK4 autophosphorylates (Gallus gallus)
CAMK4 autophosphorylates (Mus musculus)
CAMK4 autophosphorylates (Plasmodium falciparum)
CAMK4 autophosphorylates (Rattus norvegicus)
Authored
Jassal, B  (2004-03-31)
Le Novere, N  (2004-03-31)
Reviewed
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Castagnoli, L  (2008-11-06)
Created
Schmidt, EE  (2004-03-25)
Cite Us!