Reactome | Dimerization of p-S133-CREB1

Dimerization of p-S133-CREB1

Stable Identifier

R-HSA-111916

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        Dimerization of p-S133-CREB1 (Homo sapiens)
        
        PKA-mediated phosphorylation of CREB (Homo sapiens)
        
        Dimerization of p-S133-CREB1 (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        Dimerization of p-S133-CREB1 (Homo sapiens)
        
        PKA-mediated phosphorylation of CREB (Homo sapiens)
        
        Dimerization of p-S133-CREB1 (Homo sapiens)
- Signaling by Nuclear Receptors (Homo sapiens)
  - ESR-mediated signaling (Homo sapiens)
    - Extra-nuclear estrogen signaling (Homo sapiens)
      - Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Homo sapiens)
        
        Dimerization of p-S133-CREB1 (Homo sapiens)
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        NGF-stimulated transcription (Homo sapiens)
        
        Dimerization of p-S133-CREB1 (Homo sapiens)

General

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Based on studies in rat cells, activation of CREB1 by phosphorylation at serine residue S133 induces formation of CREB1 homodimers which are able to bind DNA (Yamamoto et al. 1988). The DNA binding and dimerization domains reside in the C-terminal region of CREB1 (Yun et al. 1990).

Participants

Input

x 2 p-S133-CREB1 [nucleoplasm] (Homo sapiens)

Output

p-S133-CREB1 homodimer [nucleoplasm] (Homo sapiens)

Participates

as an event of

Inferred From

Dimerization of p-S133-Creb1 (Rattus norvegicus)

Authored

Jassal, B (2004-03-31)

Le Novere, N (2004-03-31)

Reviewed

Castagnoli, L (2008-11-06)

Created

Schmidt, EE (2004-03-25)

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